Vitamin D3 Supplementation
Vitamin D3 supplementation supports bone health and reduces mortality risk, especially in older adults.
Vitamin D3 plays a crucial role in skeletal health, immune function, and metabolic regulation. Supplementation reduces the risk of fractures, especially when combined with calcium, and is associated with a significant reduction in all-cause mortality. Meta-analyses show that long-term Vitamin D supplementation reduces all-cause mortality by 6% and cancer mortality by 13%. These benefits are particularly notable in older adults, where sufficient Vitamin D levels are linked to better immune health, lower inflammation, and reduced risk of cardiovascular disease.
Potential benefits
Figures are the highest improvement reported in an individual cited study — best-case, not typical, results.
All-Cause Mortality Reduction
Cancer Mortality Reduction
Reduction in Osteoporotic Fractures and Falls
Reduced Hip Fracture Risk
Bone Mineral Density
Overall Wellness
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Sources
13 peer-reviewed references.
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- [2]doi.org/10.1101/2021.10.31.21265715
- [3]doi.org/10.1111/opn.12492
- [4]doi.org/10.1371/journal.pone.0180512
- [5]doi.org/10.1093/annonc/mdy414
- [6]doi.org/10.21608/adjalexu.2020.86764
- [7]doi.org/10.1021/acsbiomaterials.3c01779
- [8]doi.org/10.3389/fnut.2024.1381301
- [9]doi.org/10.3803/enm.2021.1374
- [10]doi.org/10.1186/s12970-019-0323-6
- [16]doi.org/10.53730/ijhs.v6ns6.10648
- [21]doi.org/10.4172/2329-6798.1000e110
- [25]doi.org/10.55640/ijmsdh-09-12-08