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Supplement

Vitamin D3 Supplementation

Vitamin D3 supplementation supports bone health and reduces mortality risk, especially in older adults.

Vitamin D3 plays a crucial role in skeletal health, immune function, and metabolic regulation. Supplementation reduces the risk of fractures, especially when combined with calcium, and is associated with a significant reduction in all-cause mortality. Meta-analyses show that long-term Vitamin D supplementation reduces all-cause mortality by 6% and cancer mortality by 13%. These benefits are particularly notable in older adults, where sufficient Vitamin D levels are linked to better immune health, lower inflammation, and reduced risk of cardiovascular disease.

Potential benefits

Figures are the highest improvement reported in an individual cited study — best-case, not typical, results.

Mortalityup to 6%

All-Cause Mortality Reduction

Mortalityup to 13%

Cancer Mortality Reduction

Bone Healthup to 13%

Reduction in Osteoporotic Fractures and Falls

Bone Healthup to 31%

Reduced Hip Fracture Risk

Bone Health

Bone Mineral Density

General Health

Overall Wellness

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Sources

13 peer-reviewed references.

  1. [1]doi.org/10.1515/cclm-2012-0599
  2. [2]doi.org/10.1101/2021.10.31.21265715
  3. [3]doi.org/10.1111/opn.12492
  4. [4]doi.org/10.1371/journal.pone.0180512
  5. [5]doi.org/10.1093/annonc/mdy414
  6. [6]doi.org/10.21608/adjalexu.2020.86764
  7. [7]doi.org/10.1021/acsbiomaterials.3c01779
  8. [8]doi.org/10.3389/fnut.2024.1381301
  9. [9]doi.org/10.3803/enm.2021.1374
  10. [10]doi.org/10.1186/s12970-019-0323-6
  11. [16]doi.org/10.53730/ijhs.v6ns6.10648
  12. [21]doi.org/10.4172/2329-6798.1000e110
  13. [25]doi.org/10.55640/ijmsdh-09-12-08

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This information is for educational purposes only and is not medical advice. Consult a qualified healthcare professional before making changes to your health regimen.